PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS Macrophage development from HSCs requires PU.1-coordinated microRNA expression
نویسندگان
چکیده
1Max-Delbrück-Center for Molecular Medicine, Berlin, Germany; 2Institute of Pathology, Charité-Universitätsmedizin Berlin, Berlin, Germany; 3Leeds Institute for Molecular Medicine, University of Leeds, Leeds, United Kingdom; 4Department of Cellular and Molecular Medicine, Hubrecht Institute, KNAW, and University Medical Center, Utrecht, The Netherlands; and 5University of California–San Diego, La Jolla, CA
منابع مشابه
Differential regulation of primitive myelopoiesis in the zebrafish by Spi-1/Pu.1 and C/ebp1.
The zebrafish has become a powerful tool for analysis of vertebrate hematopoiesis. Zebrafish, unlike mammals, have a robust primitive myeloid pathway that generates both granulocytes and macrophages. It is not clear how this unique primitive myeloid pathway relates to mammalian definitive hematopoiesis. In this study, we show that the two myeloid subsets can be distinguished using RNA in situ h...
متن کاملPU.1 regulates both cytokine-dependent proliferation and differentiation of granulocyte/macrophage progenitors.
PU.1 is a unique regulatory protein required for the generation of both the innate and the adaptive immune system. It functions exclusively in a cell-intrinsic manner to control the development of granulocytes, macrophages, and B and T lymphocytes. We demonstrate that mutation of the PU.1 gene causes a severe reduction in myeloid (granulocyte/macrophage) progenitors. PU.1 -/- myeloid progenitor...
متن کاملPHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS Essential role of spi-1–like (spi-1l) in zebrafish myeloid cell differentiation
The ETS protein Spi-1/Pu.1 plays a pivotal and widespread role throughout hematopoiesis in many species. This study describes the identification, characterization, and functional analysis of a new zebrafish spi transcription factor spi-1– like (spi-1l) that is expressed in primitive myeloid cells, erythro-myelo progenitor cells, and in the adult kidney. Spi-1l functions genetically downstream o...
متن کاملPHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS Selective roles for antiapoptotic MCL-1 during granulocyte development and macrophage effector function
During hematopoiesis, myeloid cell leukemia-1 (MCL-1) mediates the survival of bone marrow progenitors and lymphocytes. However, its requirement during myeloid cell differentiation, development, and effector function is less clear. Lineage-specific deletion of MCL-1 in myeloid precursors results in neutropenia due to death during differentiation. The loss of mature neutrophils induced by Mcl-1 ...
متن کاملDevelopmental biology of zebrafish myeloid cells.
The zebrafish (Danio rerio) has emerged as an informative vertebrate model for developmental studies, particularly those employing genetic approaches such as mutagenesis and screening. Zebrafish myelopoiesis has recently been characterized, paving the way for the experimental strengths of this model organism to contribute to an improved understanding of the genetic regulation of myeloid develop...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2011